In brief, the effect of decreasing blood glucose control with the LCD is superior to that of the LFD for Chinese patients with T2DM, yielding a lower MES at the same time. It can reduce body weight, BMI, and lipid-lowering agents. A lower demand or burden on insulin-mediated glucose disposal may play an important role in this process. Strict diet control and monitoring are the keys to managing diabetes.
Month: March 2025
Carbohydrate restriction for diabetes: rediscovering centuries-old wisdom
Reduced-carbohydrate diets have been used to treat diabetes for more than a century. After the discovery of insulin, high-carbohydrate diets became the mainstay of MNT for diabetes, not because of demonstrated superiority for long-term outcomes, but because insulin could ameliorate the acute metabolic effects of carbohydrate consumption. With new understanding of the importance of controlling postprandial hyperglycemia, mitigating glycemic variability, and ameliorating metabolic syndrome, carbohydrate restriction has gained renewed attention. Preliminary research suggests that this dietary approach might transform clinical management and perhaps normalize HbA1c for many people with diabetes, at substantially reduced treatment costs.
Impact of short-term ketogenic diet on sex hormones and glucose-lipid metabolism in overweight or obese patients with polycystic ovary syndrome
A short-term KD treatment provides significant weight loss and effectively improves hormone regulation and glucose-lipid metabolism in overweight or obese PCOS patients, offering a valuable therapeutic option for managing the condition.
Evidence for the carbohydrate-insulin model in a reanalysis of the Diet Intervention Examining The Factors Interacting with Treatment Success (DIETFITS) trial
As predicted by the carbohydrate-insulin model of obesity, weight loss in both diet groups of DIETFITS seems to have been driven by the reduction of GL more so than dietary fat or calories, an effect that may be most pronounced among those with high insulin secretion.
Psychological Support Strategies for Adults With Type 2 Diabetes in a Very Low–Carbohydrate Web-Based Program: Randomized Controlled Trial
The VLC intervention led to statistically significant improvements in glycemic control, weight loss, and depressive symptom severity. Results support the use of a VLC diet intervention in adults with T2D. The addition of monthly (not daily) dietary self-monitoring, mindful eating, and positive affect skills training did not show a definitive benefit, but it is worth further testing.
Comparing Very Low-Carbohydrate vs DASH Diets for Overweight or Obese Adults With Hypertension and Prediabetes or Type 2 Diabetes: A Randomized Trial
For adults with hypertension, prediabetes or type 2 diabetes, and overweight or obesity, the VLC diet resulted in greater improvements in systolic blood pressure, glycemic control, and weight over a 4-month period compared with the DASH diet.
Low and high carbohydrate isocaloric diets on performance, fat oxidation, glucose and cardiometabolic health in middle age males
These results: (i) challenge whether higher carbohydrate intake is superior for athletic performance, even during shorter-duration, higher-intensity exercise; (ii) demonstrate that lower carbohydrate intake may be a therapeutic strategy to independently improve glycemic control, particularly in those at risk for diabetes; (iii) demonstrate a unique relationship between continuous glycemic parameters and systemic metabolism.
A bibliometric and visual analysis of low carbohydrate diet
Nutrients was the leading journal. “A randomized trial of a low-carbohydrate diet for obesity” and “Obesity” were considered to be the most co-cited and cited reference respectively. The hotspots of LChD are four aspects, “ketogenic diet”, “metabolism disease”, “cardiovascular disease” and “cancer”. We summarized that “oxidative stress”, “gut microbiota”, and “inflammation factors” are becoming frontiers trends of LChD research in the future and deserve further study.
Ketogenic state improves testosterone serum levels-results from a systematic review and meta-analysis
Comprehensively, KD improved testosterone levels depending on both patients’ age and KD-induced weight loss. However, the lack of information in included studies on hormones of the hypothalamic-pituitary-gonadal axis prevents an exhaustive comprehension about mechanisms connecting ketosis and testosterone homeostasis.
Prolonged remission followed by low insulin requirements in a patient with type 1 diabetes on a very low-carbohdyrate diet
A report a case of a patient with a late-onset classic presentation of T1DM who adopted a very low-carbohydrate diet and completely avoided insulin therapy for 18 months, followed by tight glycemic control on minimal insulin doses.