Efficacy and Safety of a High Protein, Low Carbohydrate Diet for Weight Loss in Severely Obese Adolescents

Significant reduction in BMI-Z-score was achieved in both groups during intervention, and was significantly greater for the HPLC (high protein low carbohydrate) group. Both groups maintained significant BMI-Z reduction at follow-up; changes were not significantly different between groups. The HPLC diet is a safe and effective option for medically supervised weight loss in severely obese adolescents.