A randomized trial of a low-carbohydrate diet vs orlistat plus a low-fat diet for weight loss.
Obese and overweight outpatients were assigned to either a low-carbohydrate ketogenic diet (LCKD) or Orlistat therapy combined with a low fat diet (O + LFD). In a sample of medical outpatients, an LCKD led to similar improvements as O + LFD for weight, serum lipid, and glycemic parameters and was more effective for lowering blood pressure.
References:
Yancy (2010). "A randomized trial of a low-carbohydrate diet vs orlistat plus a low-fat diet for weight loss." Arch Intern Med 170(2):136-45.