Obese and overweight outpatients were assigned to either a low-carbohydrate ketogenic diet (LCKD) or Orlistat therapy combined with a low fat diet (O + LFD). In a sample of medical outpatients, an LCKD led to similar improvements as O + LFD for weight, serum lipid, and glycemic parameters and was more effective for lowering blood pressure.
Category: Weight Loss
Effects of Two Weight-loss Diets on Health-related Quality of Life.
Mental aspects of HRQOL (health related quality of life) improved more in participants following an LCKD (low calorie ketogenic diet) than an LFD (low fat diet), possibly resulting from the LCKD’s composition, lack of explicit energy restriction, higher levels of satiety or metabolic effects. The factors analyzed were: Physical Functioning, Role-Physical, General Health, Vitality, Social Functioning. The Physical Component Summary score improved similarly in both diet groups. Bodily Pain improved in the LFD group only, whereas the Role-Emotional and Mental Health subscales and the Mental Component Summary (MCS) score improved in the LCKD group only.
A Low-carbohydrate, Ketogenic Diet to Treat Type 2 Diabetes
In a study of overweight individuals with type 2 diabetes, the LCKD (low carbohydrate ketogenic diet) improved glycemic control in patients with type 2 diabetes such that diabetes medications were discontinued or reduced in most participants. Other results include: mean body weight decreased by 6.6% and fasting serum triglyceride decreased 42%.
A Low-Carbohydrate, Ketogenic Diet for Type 2 Diabetes Mellitus
The LCKD reduced glycemia, body weight and serum triglycerides in type 2 diabetic patients but close medical supervision was required to adjust diabetic and blood pressure medications.
A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet To Treat Obesity and Hyperlipidemia: A Randomized, Controlled Trial
Compared with a low-fat diet, a low-carbohydrate diet program had better participant retention and greater weight loss. During active weight loss, serum triglyceride levels decreased more and high-density lipoprotein cholesterol level increased more with the low-carbohydrate diet than with the low-fat diet.
A Pilot Trial of a Low-Carbohydrate, Ketogenic Diet in Patients with Type 2 Diabetes
The study focused on overweight individuals with BMI >25 and being treated with OHA (oral hypoglycemic agents) or insulin that were placed on a LCKD (low carbohydrate ketogenic diet) for 16 weeks. Anthropometric changes include: Body weight = -10%, BMI = -10%, Waist circumference = -7%, Body fat % = -3%, Systolic BP = -9%, Diastolic BP = -15%, Heart Rate = -12%, HDL = no change.
A Pilot Study of a Low-Carbohydrate, Ketogenic Diet for Obesity-Related Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, and is frequently associated with central obesity, insulin resistance, and dyslipidemia. Because recent evidence demonstrates that a low carbohydrate ketogenic diet (LCKD) leads to weight loss and improvements in insulin sensitivity, we conducted this uncontrolled trial of the diet for PCOS.
Effects of Diet Composition on Postprandial EnergyAvailability during Weight Loss Maintenance
These findings suggest that a Low Fat diet may adversely affect postprandial Energy Availability and risk for weight regain during weight loss maintenance.
Body Composition and Hormonal Responses to a Carbohydrate-restricted Diet
Authors conclude that a carbohydrate-restricted diet resulted in a significant reduction in fat mass and a concomitant increase in lean body mass in normal-weight men, which may be partially mediated by the reduction in circulating insulin concentrations.
Comparison of a Very Low-Carbohydrate and Low-Fat Diet on Fasting Lipids, LDL Subclasses, Insulin Resistance, and Postprandial Lipemic Responses in Overweight Women
Compared to a low-fat weight loss diet, a short-term very low-carbohydrate diet did not lower LDL-C but did prevent the decline in HDL-C and resulted in improved insulin sensitivity in overweight and obese, but otherwise healthy women. Small decreases in body mass improved postprandial lipemia, and therefore cardiovascular risk, independent of diet composition.